Phosphoinositide 3-kinase—Akt (PI3K-Akt) signaling pathway: a report demonstrated that PI3K-Akt signaling pathway was excessively activated, aggravating in overexpression Bcl-2, Mcl-1, and FLIP to result in unbalanced apoptosis of synovial cells, which is associated with occurrence and progression of RA [46,47]. The gene discussed is BCL2; the disease is rheumatoid arthritis.