Although its prognostic significance (HR = 1.767, p = 0.002327) was not as high as that of BICD1 (HR = 2.731, p = 0.000002) in LGGs (Figure 2B), the strong correlation between BICD1 downregulation and a decreased level of CD274 (PD-L1) still highlighted the possibility that BICD1 downregulation contributed to a favorable outcome in LGGs, which might be associated with an enhanced immune surveillance in cancer patients. The gene discussed is CD274; the disease is cancer.