EGFR and central nervous system cancer: Although BICD1 expression was not significantly corelated with 1p19q codeleted status, it was significantly upregulated in IDH1 wild-type LGGs with EGFR mutations, which was the subgroup of LGGs with the poorest prognosis, and could be considered as glioblastoma (grade IV glioma), rather than LGGs, according to the 2016 WHO classification of CNS tumors (Figure 4C).