INS and Insulin resistance: The sericin extracted from a boiled solution of colored cocoons enhances the insulin PI3K/AKT signaling pathway in the liver of a T2D rat [21], reduced the destruction of pancreatic islet cells, protected kidney and other organs [22], improved insulin resistance [23], promoted corneal wound healing [24], improved the observed disorder in the growth hormone/insulin-like growth factor 1 axis, and reduced hippocampal damage in T2D rats [25].