Dissection of the PEA analysis combined with reactome mining emphasized that a set of ten genes (PIK3CA, PIK3CB, PIK3CD, ESR1, KIT, MTOR, HSP90AA1, MAPK1, KDR, and MDM2) were significantly modulated as biological targets to ST-1 as a potent anti-ulcer drug. The gene discussed is MAPK1; the disease is ulcer disease.