In several studies, Nf levels in plasma and CSF showed a significant correlation with disease severity, such as a decline in the Amyotrophic Lateral Sclerosis Functional Rating Scale—Revised (ALSFRS-R), diagnostic latency, shorter survival, and time to generalization [69,73,74,75,76,143]. Here, NFASC is linked to amyotrophic lateral sclerosis.