For example, the well-recognized cancer-driving EGFR mutation, L858R (c.2573T>G), introduces a 5′–GGGCUGG–3′ to 5′–GGGCGGG–3′ change in the sequence of the EGFR mRNA, creating a potential target for G-rich oligonucleotides [90]. The gene discussed is EGFR; the disease is cancer.