Consistent with findings from patients with AD, retinal plaques have also been reported in pre-symptomatic 3xTg-AD [61], Tg2576 [62,77], PSAPP [62], APP/PS1 [60,76,78,79], and 5xFAD mouse models of AD [62,80] and in the APPNL-G-F knock-in mouse model [63]. This evidence concerns the gene APP and Alzheimer disease.