MAPT and Alzheimer disease: In human glaucoma, abnormal tau (AT8) is localized in the INL [102], and in the rat glaucoma model, retinal tau (K9JA) accumulates dramatically in the IPL and is modestly increased in the GCL [166], while tau accumulates in the OPL, GCL, IPL, and RNFL of the retina in AD.