MAPT and Alzheimer disease: Furthermore, oligomeric tau is observed in the retina of tauopathy mice (i.e., P301L tau transgenic mice) and patients with AD or frontotemporal lobar dementia and is colocalized with Iba1-labeled microglia, GFAP-labeled astrocytes, and the pro-inflammatory cytokine HMGB1; these findings suggest that tau aggregates are associated with retinal inflammation [101].