NNMT and cancer: In fact, NNMT overexpression has been reported for many solid tumors, including gastrointestinal neoplasms [40,41,42,43,44,45,46,47,48], lung [49,50,51,52], oral [53,54,55,56,57,58,59], esophageal [60,61], nasopharyngeal [62] and thyroid [63,64,65] cancers, as well as ameloblastoma [66] and glioblastoma multiforme [67].