ITGB4 and melanoma: The expression profile in melanoma for the most expressed genes in normal skin tends to follow the same profile, except that integrin beta-4 (ITGB4) and integrin alpha-5 (ITGA5) have lower expression levels, and integrin alpha-3 (ITGA3) and integrin alpha-6 (ITGA6) have higher expression levels in melanoma (Figure 4).