It is interesting to note that the cadherins that have reduced protein expression levels in melanoma (Figure 2A) tend to be mainly expressed on melanocytes and keratinocytes and are approximately balanced in skin (Figure 2B) (e.g., desmoglein-1, desmocollin-3, desmocollin-1, calsyntenin-1, desmoglein-3), reinforcing that a loss of cell adhesion between melanocytes and keratinocytes is a critical event in melanoma. Here, DSC3 is linked to melanoma.