BRAF and neoplasm: They discovered a high density of neutrophils and macrophages in tumors with wild-type epidermal growth factor receptor (EGFR) and a high density of neutrophils in tumors with b-raf proto-oncogene (BRAF) mutation, which affects the ability of tumor cell mutational status to change the pattern of cytokines and chemokines released by tumor cells and, thus, influences the TME’s chemoattractant properties.