We found two combinations that can distinguish lung cancer patients with stage IIB from those with IIA with 100% sensitivity and 100% specificity, wherein IL-6, glucose, and LDH has an AUC = 0.8333 and the combination of CEA, IL-6, SAA1, MMP-9, and lactate an AUC = 1.0000. The gene discussed is MMP9; the disease is lung cancer.