ARRDC3 and breast carcinoma: ARRDC3 is a metastasis inhibitor that can induce NEDD4-dependent ubiquitination of ITG β4 and targeting of endosomal integrin β4 into lysosomes, thereby reducing the level of integrin β4 in extracellular vesicles, to reduce the metastasis potential of the extracellular vesicles of breast cancer cells.