TP53 and neoplasm: Studies showed that after ionizing radiation exposure, cell integrin β4 tyrosine residue 1510 is phosphorylated, which leads to the activation of the integrin α6β4–Src–AKT signaling pathway, and then leads to the disappearance of p21 targeted by p53, prevents the activation of photoproteinase, and causes tumor cells to age during radiation exposure.