Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer [33]; its pathway genes PIK3CA and AKT1, and other known signal partners, such as MET and FYN, etc., were found to be strongly related to integrin β4 [17]. The gene discussed is PIK3CA; the disease is cancer.