However, another study by Bernatchez and colleagues [24] found that while the basic fibroblast growth factors (bFGF) and the VEGF receptor flk-1, which produce a positive proliferation signal, were expressed in hemangioma, there was no expression of the VEGF receptor flt-1, which negatively regulates endothelial proliferation [25]. This evidence concerns the gene FLT1 and hemangioma.