SETD2 and nonpapillary renal cell carcinoma: Because ccRCC is also characterized by mutations in genes that are involved in chromatin remodeling and epigenetic regulations such as BAP1, KDM5C, MTOR, PBRM1, SETD2, and VHL [37,38,39,40,41,42], we examined the effects of the most commonly altered genes on ZNF433 expression.