SETD2 and cancer: SETD2 encodes a methyltransferase that specifically trimethylates lysine-36 of histone H3 (H3K36me3), whereas KDM5c (also known as JARID1C) is a gene that encodes an H3K4me2/3 demethylase that plays a central role in transcriptional repression and can mediate cancer progression [44].