We reviewed data from the most promising candidate biomarkers of BRCAness in GBM, namely mutate isocitrate dehydrogenases 1 and 2 (IDH1/2), EGFR mutated variant (EGFR vIII), phosphatase and tensin homolog (PTEN), MYC oncogene, and the estrogen receptors beta (ERβ). This evidence concerns the gene ESR2 and glioblastoma.