As a dietary supplement, isoliquiritigenin was found to induce demethylation of the promoter of WNT inhibitory factor 1 (WIF1) by blocking the catalytic domain of DNMT1, leading to increased WIF1 gene expression and, thereby, halted the cancer development process in mammary tissue via inhibition of BC stem cells [90]. The gene discussed is DNMT1; the disease is breast cancer.