In Cxcr2 knockout PKF (LSL-KrasG12D/+; Tgfbr2flox/flox, Ptf1a-Cre) mice, infiltration of myeloperoxidase+ (MPO+) neutrophils and CD11b+Ly6G+ MDSCs to tumor is decreased compared to control animals [34]. The gene discussed is CXCR2; the disease is neoplasm.