In a KPC (LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx1-Cre) mouse model, the secretion of Cxcl1, Cxcl2, and Cxcl5 from tumor cells is increased and related to high numbers of MPO+ neutrophils compared to the normal pancreas [29]. Here, MPO is linked to neoplasm.