Interestingly, dissecting the ING3 expression levels for each Gleason score, the data suggest an increase of ING3 mRNA levels up to Gleason score 8, whereas the samples with a higher Gleason score of 9 and 10 revealed a decline of ING3 expression (Figure 7B), indicating a lower ING3 expression in higher metastatic PCa. Here, ING3 is linked to posterior cortical atrophy.