NFYA and cancer: In cancer, Hung et al. demonstrated that the lnc-RNA named PANDA interacts with the TF NF-YA, generating a negative feedback regulation on the expression of pro-apoptotic genes, including APAF1, BIK, FAS and LRDD [52], this happens because NF-YA cannot interact with the DNA binding sites of its target gene and subsequently an inhibition on gene expression is achieved [53] (Figure 2A).