Axin2+ SuSC-specific disruption of Bmpr1a in mice, namely, Axin2Cre-Dox;Bmpr1aflox/flox mice, resulted in precocious differentiation and aberrant ossification, leading to craniosynostosis, which initiated at the midline of the suture [10]. The gene discussed is AXIN2; the disease is craniosynostosis.