Importantly, molecules specifically inhibiting BDII, like RXV-2157 and apabetalone, efficiently blocked SARS-CoV-2 infection by decreasing ACE2 expression and thereby SARS-CoV-2 S protein binding, showing that selective inhibitors against BDII are potential candidates to prevent heart damage caused by COVID-19 [21]. The gene discussed is ACE2; the disease is COVID-19.