In addition, TERT mRNA levels were elevated in approximately 4% of untreated tumors that lacked genomic aberrations in TERT or MYCN. NB with TERT rearrangements, MYCN amplification, or high TERT expression without these alterations were associated with unfavorable prognostic variables and adverse patient outcomes [8,9,27]. This evidence concerns the gene TERT and neuroblastoma.