Moreover, 6-thio-dG strongly impaired tumor growth in NB xenograft models with TERT activation, but exerted weaker effects on MYCN-amplified NB, likely due to the additional oncogenic pathways activated by MYCN. Additional in vivo studies are needed to evaluate the antitumor effect of 6-thio-dG in MYCN-amplified NB. Here, MYCN is linked to neuroblastoma.