SIRT1 and type 1 diabetes mellitus: Dividing T1DM patients into two groups according to the presence (T1DM + HD) or absence of HD (T1DM − HD), a higher sirtuin 1 concentration was found in the T1DM + HD group (32.68 ± 86.06 ng/mL vs. 2.76 ± 4.88 ng/mL.