Another studies showed that intermittent hypoxic conditions after brain ischemia displayed a neuroprotective effect, and despite relatively high expression of HIF-1α, lower expression of iNOS in the border between infarcts and normal tissue was observed, suggesting that overactivation of HIF-1α may suppress the activation of microglia in ischemic mice [104]. The gene discussed is HIF1A; the disease is brain ischemia.