In the models of permanent MCAO or acute phase of ischemic stroke in mice the expression of HIF-1α was enhanced in the place of injury, causing the massive production of iNOS [103], indicating that activation of HIF-1α might be involved in the mechanisms through which iNOS promotes cell death or survival constituting a critical factor in widespread inflammation and subsequent pathological events. The gene discussed is HIF1A; the disease is ischemic stroke.