CXCL8 and cancer: It is concluded that RA-RF markedly suppressed the ROS production induced by PMFF, resulting in reduced IL-6, IL-8, TNF-α, and COX-2 mRNA expression and inhibited the metastasis cascade affecting MMP-9 activity, which reduced cancer cell invasion and migration via the AP1, NF-κB, and Akt signaling pathways.