While PRMT2 status and role in gastric cancer does not seem to be previously investigated, our observation on diminished PRMT2 expression in cardia tumors is in line with antitumor activity played by peroxisome proliferator-activated receptor γ (PPARγ) in gastric carcinogenesis [46], even though the receptor is reportedly upregulated in gastric tumors [47]. The gene discussed is PRMT2; the disease is gastric neoplasm.