While PRMT2 status and role in gastric cancer does not seem to be previously investigated, our observation on diminished PRMT2 expression in cardia tumors is in line with antitumor activity played by peroxisome proliferator-activated receptor γ (PPARγ) in gastric carcinogenesis [46], even though the receptor is reportedly upregulated in gastric tumors [47]. This evidence concerns the gene PRMT2 and gastric cancer.