FOXA1 and Patent ductus arteriosus: Similar to FOXA1-dependent enhancer reprogramming, this study found that p63 increases H3K27ac occupancy at the enhancers of squamous lineage genes, resulting in increased transcriptions of genes including KRT5/6, TRIM29, and PTHLH. Together, the squamous transcriptional program governed by epigenetic mechanisms promotes aggressive PDA phenotypes in vivo [17].