In addition to the germline mutations in PDA, whole exome and genome sequencing revealed that a significant percentage of patients with PDA have somatic mutations in epigenetic regulators and chromatin remodeling complexes (e.g., ARID1A/B, PBRM1, MLL2/3/4, KDM6A, SMARCA2/4) [6,7]. Here, KMT2D is linked to Patent ductus arteriosus.