To obtain proof of principle for the potential role of the host’s C/EBPδ expression in pancreatic cancer and metastatic disease, wildtype and C/EBPδ-/- mice were subjected to an orthotopic pancreatic cancer model where C/EBPδ proficient murine pancreatic cancer cells were orthotopically injected into the pancreas. Here, CEBPD is linked to familial pancreatic carcinoma.