ARHGEF25 and hypertensive disorder: The protein expression of the RhoA active form, RhoA membrane translocation implying RhoA activation, and phosphorylation of MYPT1 increased in the aortas or VSMC from hypertensive models [25,26,27], and p63RhoGEF mRNA and protein expression increased in the peripheral blood mononuclear cells from essential hypertensive patients [28].