For example, the actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), functioning as an endogenous RNA, competitively binds to miR-384, regulating the expression of the Activin Receptor A type I (ACVR1) and inhibiting the stemness of pancreatic cancer cells and tumorigenicity in nude mice [239]. Here, ACVR1 is linked to familial pancreatic carcinoma.