NANOG and malignant colon neoplasm: In fact, in colon cancer cells (Caco-2, LS174T, LoVo, HT-29, HCT116, SW480, and SW620) and human colorectal cancer tissues, NANOG directly represses the transcription of mir-200b/c genes, modulating EMT to mesenchymal–epithelial transition plasticity [53].