In detail, the suppression of the stem-cell-like signature induced by the miR-302-367 cluster in glioma-initiating cells is mediated by the drastic downregulation of the pathway mediated by the chemokine receptor CXCR4 and its ligand SDF1, because miR-302a binds to the CXCR4 3′-UTR. Here, CXCR4 is linked to glioma.