CBS and cancer: We went on to show that CBS expression was increased in human adenomatous polyps and that experimental upregulation of CBS in a premalignant colonic epithelial cell line, NCM356, caused extensive metabolic reprogramming and induction of an invasive tumorigenic phenotype, supporting the conclusion that enhanced CBS activity not only contributes to the progression and the spread of established cancer, but also promotes colon carcinogenesis [20].