MAPT and Huntington disease: For example, in Alzheimer’s Disease (AD), there is the deposition of protein aggregates, extracellular amyloid plaques (Aβ), intracellular tau (τ) or neurofibrillary tangles [18,19]; in Parkinson’s Disease (PD), there is an impairment of dopaminergic neurons (DA) [20]; in amyotrophic lateral sclerosis (ALS) and Huntington Disease (HD), the mechanisms are still uncertain, but the substantia nigra is thought to have elevated levels of oxidized lipids, proteins and DNA [21,22,23,24,25].