Prader–Willi syndrome (PWS) is a rare genetic condition with an estimated prevalence of about 1:15,000 that is characterized by multisystemic features, such as severe early hypotonia, hyperphagia, childhood obesity, short stature, small hands and feet, hypogonadism, growth hormone or other endocrine deficiencies, craniofacial dysmorphisms, developmental delay, intellectual disability (ID), behavioral disturbances, and autism spectrum disorder [1]. This evidence concerns the gene GH1 and hypogonadism.