Moreover, studies by Tiwari et al. [40] found that ETS reverses amyloid-induced β (Aβ) deficits in learning and memory in a rat model of Alzheimer’s disease-like phenotypes by activation of the PI3K/Akt/Wnt/β-catenin pathway. The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.