UCN and major depressive disorder: The sexual dimorphism of Ucn-1 neurons in EWcp might be related to the different stress response strategies adopted by males (‘fight-or-flight’) and females (‘tend-and-befriend’) [48], as well as the higher vulnerability of females to develop stress-related disorders, such as depression and anxiety, possibly because of cycling through low estrogen phases that are associated with low Ucn-1 expression in EWcp.