Interestingly, Ucn-1 and BDNF mRNA expression in EWcp was altered in suicide victims in a sex-dependent manner (males had 11 times more Ucn-1 mRNA and 4 times less BDNF mRNA in EWcp than females), suggesting that EWcp might contribute to the pathogenesis of major depression [251], which is more prevalent in females. Here, BDNF is linked to major depressive disorder.