The discrepancy between the results from centrally administered Ucn-1 studies and those from Ucn-1 knockout mice might be due to the possibility that centrally administered Ucn-1 could activate CRF-R2 as well as CRF-R1, which are not normally accessed by endogenous Ucn-1, resulting in the reported anxiety-like behavior. This evidence concerns the gene CRHR2 and Anxiety.