While some discrepancies are observed between human and rodent models, a clear pattern of receptor distribution is found on the upper motor neuron, which given the role of NPY in conferring neuroprotection in neurodegenerative diseases, makes this system and this receptor worthy of future studies that aim to explore the potential to modulate motor neuron function to alleviate motor symptoms in ALS. The gene discussed is NPY; the disease is amyotrophic lateral sclerosis.