This effect, likely mediated by the pro-inflammatory cytokine IL-1β, which downregulates the transcription of KCC2, is particularly relevant because MIA is one of the more promising murine models of Autistic Spectrum Disorders (ASD) [41], but has also been linked to enhanced risk of schizophrenia in humans [42]. The gene discussed is SLC12A5; the disease is schizophrenia.