Since bumetanide is a diuretic drug, prescribed to reduce symptoms of fluid retention or edema in people with congestive heart failure, liver or kidney disease, as such, is not devoid of side effects, as it inhibits both the ubiquitous isoform NKCC1 and the kidney-specific NKCC2, with consequent diuretic effects. This evidence concerns the gene SLC12A1 and kidney disorder.