SIRT1 and obesity due to melanocortin 4 receptor deficiency: Some studies have shown that the ethyl acetate fraction of chrysanthemum indicum (CIEA) might be beneficial for preventing obesity [27,28,29], and in vitro chrysanthemum morifolium flower extract inhibits adipogenesis of 3T3-L1 cells via AMPK/SIRT1 pathway activation [30].