TF and ischemic stroke: The reduction of TSAT by DFO might well be meaningful to the final outcome in the patients according to the fact that: (1) reduction of TSAT by IV administration of iron-free Tf (apotransferrin) at reperfusion has demonstrated neuroprotective and found associated to better outcome in experimental ischemic stroke models [12]; and (2) blood TSAT at reperfusion positively correlated with infarct volume and neurological impairment in experimental stroke; in rats, a 25% reduction in transferrin saturation decreases ischemic brain damage accordingly [12].