GPX4 and epilepsy: In this pilot cross-sectional study, we investigated if ferroptosis occurs in children with epilepsy by measuring the blood content of the “pathogenic triad” of ferroptosis bio-markers [8,12,13,14]; (i) 4-HNE and 15(S)-HETE, the main lipid peroxidation by-products [15,16]; (ii) GPX4, the principal lipid peroxides detoxifying enzyme [17]; and (iii) GSH, the primary ROS scavenger and cofactor for the GPX4 activity.