MAPT and Alzheimer disease: The neuropathological features of AD are represented by the brain accumulation of extracellular senile plaques and fibrils composed by aggregated amyloid-β-peptides, intracellular neurofibrillary tangles (NFTs) mainly consisting of hyperphosphorylated tau protein, microglial infiltration, neuroinflammation and significant neuronal loss [17,18].