With respects to myokines—the response to muscle contraction during exercise—IL-6 and IL-10 may balance and counteract the effects of pro-inflammatory adipokines such as leptin [53], where the associations between skeletal muscle, the cardiovascular system and adipose tissue have been identified to play a key role in the regulation of blood pressure and the development of hypertension [63]. Here, LEP is linked to Hypertension.