In addition, Ca2+ entry via TRPM2 channels in pancreatic ß-cells, neutrophils, and endothelial cells, among other cell types, undoubtably contributes to the onset and progression of liver pathologies associated with type 2 diabetes, hepatitis, and other liver diseases involving ROS and inflammatory pathways [33,34,35,91,92]. This evidence concerns the gene TRPM2 and liver disorder.