From a clinical point of view, blockade of Ang II production or AT1R signaling and/or NOX2 may be helpful to retain or restore vascular endothelial function in various age-related diseases associated with endothelial dysfunction in ocular blood vessels, such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Here, CYBB is linked to age-related macular degeneration.