We previously reported that NOX2 contributes to endothelial dysfunction in a variety of ocular disease models, such as acute respiratory distress syndrome, ischemia-reperfusion injury, hypercholesterolemia, and glaucoma, highlighting the critical pathophysiological role of NOX2 in the ocular vascular system [44,46,57,58]. This evidence concerns the gene CYBB and Hypercholesterolemia.