The main enriched pathways were: interferon-gamma signalling pathway, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signalling pathway, Toll-like receptor signalling pathway, Alzheimer’s disease-amyloid secretase pathway, rat sarcoma virus (RAS) pathway, B cell activation, Gastrin and cholecystokinin receptors (CCKR) signalling map, oxidative stress response. The gene discussed is SOAT1; the disease is early-onset autosomal dominant Alzheimer disease.