MAPT and Alzheimer disease: This results in aberrant redox reactions and severing/depolymerizing F-actin, tau hyperphosphorylation, and endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which eventually leads to synaptic dysfunction and cognitive impairment and triggers the process of neurodegeneration in AD [56,57,58,59,60,61,62].