GPX1 and Hyperglycemia: PMNs are activated under chronic hyperglycemia and play a crucial role in CVDs by promoting cellular and endothelial impairment due to vessel recruitment and leukocyte aggregation [3] or through reactive oxygen species (ROS) production, which reduces antioxidant defense systems such as superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPX1), thus leading to oxidative stress.