It is at these elevated levels that P-AscH− is selectively cytotoxic to cancer cells via generation of H2O2 and has proven to be a safe adjuvant to standard of care therapy in our clinical trials [75,76] Interestingly, SOD mimetics have been shown to enhance the cytotoxic effects of P-AscH− in pancreatic cancer [77]. This evidence concerns the gene SOD1 and cancer.