The antioxidant effects of Loni and anthocyanin treatments have been demonstrated also in rat cortical cells by protecting against glutamate-induced toxicity [33] or in the animal models of Alzheimer disease by the regulation of the phosphorylated-phosphatidylinositol 3-kinase-Akt-glycogen synthase kinase 3 beta pathway [34]. The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.