It has been reported that glycyrrhizic acid ameliorates HG-induced low expression and activity of AMPK, Sirt1, and SOD2 in renal tubular cells and improves DKD in a mouse model of type 2 diabetes by suppressing ROS and activating the AMPK/Sirt1 pathway [123]. This evidence concerns the gene SOD2 and type 2 diabetes mellitus.