In the present study, despite comparable upregulation of myocardial SGLT1 protein expression in pressure and volume overload-induced chronic HF, the activating phosphorylation of ERK1/2 was preserved in TAC hearts (pressure overload for 14 weeks), whereas it was significantly downregulated in those with ACF (volume overload for 24 weeks). Here, MAPK3 is linked to persistent truncus arteriosus.