SLC5A1 and persistent truncus arteriosus: In the present study, despite comparable upregulation of myocardial SGLT1 protein expression in pressure and volume overload-induced chronic HF, the activating phosphorylation of ERK1/2 was preserved in TAC hearts (pressure overload for 14 weeks), whereas it was significantly downregulated in those with ACF (volume overload for 24 weeks).