Extracellular signal-regulated protein kinase (ERK) 1/2 and adenosine monophosphate-activated protein kinase (AMPK) have been implicated as positive regulators of SGLT1 expression in the heart during myocardial ischemia-reperfusion injury [7], whereas genetic overactivation of myocardial AMPK and resultant cardiomyopathy is associated with upregulation of SGLT1 [8]. Here, SLC5A1 is linked to cardiomyopathy.