Further to this, we demonstrate for the first time that TAC-induced chronic HF for 14 weeks is associated with increased LV SGLT1 expression on the protein level, in line with upregulation of the mRNA expression of pathological hypertrophy markers (β/α-MHC ratio, CTGF, Col1a1, and TGF-β). The gene discussed is CCN2; the disease is hydrops fetalis.