SLC5A1 and myocardial ischemia: Similarly, previous studies noted that SGLT1 expression was upregulated in non-diabetic small animal models of acute myocardial ischemia-reperfusion injury [7], and permanent left anterior descending coronary artery ligation (model of ischemic heart disease) [1,31], as well as in models of metabolic syndrome/T2DM [1,4,5,30].